Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains
نویسندگان
چکیده
منابع مشابه
Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains.
Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly. Santiago and Potashkin (1) recently performed a network-based metaanalysis of four independent microarray datasets and identified hepatocyte nuclear factor 4 alpha (HNF4A) and polypyrimidine tract binding protein 1 (PTBP1) to be the longitudinally dynamic biomarkers for PD. They found that HNF4A is a ce...
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An expression Quantitative Trait Locus or eQTL is a chromosomal region that accounts for a proportion of the variation in abundance of a mRNA transcript observed between individuals in a genetic mapping population. A single gene can have one or multiple eQTLs. Large scale mRNA profiling technologies advanced genome-wide eQTL mapping in a diverse range of organisms allowing thousands of eQTLs to...
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The last few years have seen the development of large efforts for the analysis of genome function, especially in the context of genome variation. One of the most prominent directions has been the extensive set of studies on expression quantitative trait loci (eQTLs), namely, the discovery of genetic variants that explain variation in gene expression levels. Such studies have offered promise not...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1509048112